TABLE 14-4

Carcinogenicity of Polychlorinated Biphenyls (PCB's)'

Compound

Mutagenicity and
Related Tests

Aroclor 1221 and
1268

Aroclor 1242

Aroclor 1254

Aroclor 1260

Kanechlor 300
Kanechlor 400

Kanechlor 500

Mutagenlc to S^. typhimurium
(Wyndham e£ al., 1976)

Did not induce chromosome aberra-
tions in bone marrow (Green et al.,
1973, 1975a)

Did not induce chromosome aberra-
tions in bone marrow of rats (Green
jet al., 1973, 1975a); negative in
dominant lethal assay in rats
(Green <e_t al., 1975b); did not Induce
chromosome aberrations in human
lymphocytes in culture (Hoopingarner
et al., 1972)

Carcinogenicity (Oral
Administration Only)

Increased the incidence of hepatomas in BALB/cJ
mice (Kimbrough and Linder, 1974); promoted
hepatocellular carcinomas induced by
NDEA in rats (Preston et al., 1981)

Induced dose-related increase in hepatocellular
carcinomas in female Sherman rats (Kimbrough
et al., 1975)

Increased the incidence of hepatocellular carcinomas
in dd mice (Ito e± al., 1973)

Increased the incidence of hepatocellular carcinomas
in dd mice (Ito et. al., 1973); enhanced hepatomas in
rats when fed after 3f-DMAB (Kimura e£ al., 1976);
enhanced hepatocarcinogenlcity of lindane in mice
(Nagasaki et al., 1975)

Increased the incidence of hepatocellular carcinomas
in dd mice (Ito e£ al., 1973); enchanced liver tumors
in rats when fed after NDEA (Nishizumi, 1976), but
when fed in combination with 3f-DMAB, 2-AAF, and NDEA,
it Inhibited hepatocarcinomas in rats (Makiura ejt
al., 1974); enhanced hepatocarcinogenicity of lindane
in mice (Nagasaki e£ al^, 1975).

aThe tolerance levels for PCB's in various food products range from 0.2 to 5 jag/g fat (U.S. Food and Drug
Administration, 1977b). From 1974 to 1977, daily dietary intake ranged from 0 to 0.0164 yg/kg bw (U.S. Food and Drug
Administration, 1980b).